文章详情

题名 · 作者 · 摘要 · 关键词 · DOI · 参考文献

基于CiteSpace的人工智能在阿尔茨海默病研究中的应用可视化分析

赖胜圣1,张刚平1,刘文平1,陈灿洋1,2

(1.广东食品药品职业学院 医疗器械学院,广东 广州 510520; 2.广东医科大学 生物医学工程学院,广东 东莞 523808)

栏目:信息化应用 · 第 2025 年第 9 期 · 页码:136-145,150 · 2096-4706(2025)09-0136-11 · 中图分类号:TP391.4 · 文献标识码:A · DOI:10.19850/j.cnki.2096-4706.2025.09.026

摘要

该研究通过文献计量分析,探讨人工智能在阿尔茨海默病研究中的发展趋势和应用热点。基于Web of Science核心数据库,检索了2013—2023年间的3 680篇相关文献,利用CiteSpace软件进行共现分析与关键词聚类,分析了发文趋势、国家和机构的合作情况、核心作者及共被引文献等。研究结果表明,人工智能在阿尔茨海默病领域的应用主要集中在影像数据分析与早期诊断、多模态数据融合以及脑网络功能连接三个方向。同时,任务分析和迁移学习作为新兴热点,显示了人工智能在个体化诊断和长期病情管理中的潜力。从结果分析可知,人工智能在阿尔茨海默病诊断与治疗中的应用正处于快速发展阶段,未来研究将聚焦于算法的泛化能力提升和多模态数据处理能力,以提供更加精准的诊断和个体化治疗方案。

关键词

阿尔茨海默病;可视化分析;多模态数据融合;神经网络;机器学习

参考文献

  1. [1] WORLD HEALTH ORGANIZATION. Global Status Report on the Public Health Response to Dementia [J].World Health Organization,2021:272.
  2. [2] FABRIZIO C,TERMINE A,CALTAGIRONE C,et al. Artificial Intelligence for Alzheimer's Disease: Promise or Challenge? [J/OL].Diagnostics,2021,11(8):1473[2024-09-27].https://doi.org/10.3390/diagnostics11081473.
  3. [3] 陈悦,陈超美,刘则渊,等.CiteSpace知识图谱的方法论功能 [J].科学学研究,2015,33(2):242-253.
  4. [4] CHEN C M. Visualizing and Exploring Scientific Literature with CiteSpace: An Introduction [C]//Proceedings of the 2018 Conference on Human Information Interaction & Retrieval. New Brunswick:ACM:2018:369-370.
  5. [5] LECUN Y,BENGIO Y,HINTON G. Deep Learning [J].Nature,2015,521(7553):436-444.
  6. [6] KONG X J,SHI Y J,YU S,et al. Academic Social Networks: Modeling, Analysis, Mining and Applications [J].Journal of Network and Computer Applications,2019,132:86-103.
  7. [7] ASSOCIATION A. 2018 Alzheimer's Disease Facts and Figures [J].Alzheimer's & Dementia,2018,14(3):367-429.
  8. [8] RESCE G,ZINILLI A,CERULLI G. Machine learning prediction of academic collaboration networks [J/OL].Scientific Reports,2022,12(1):21993[2024-10-03].https://www.nature.com/articles/s41598-022-26531-1.
  9. [9] REN R J,QI J L,LIN S H,et al. The China Alzheimer Report 2022 [J].General Psychiatry,2022,35(1):1-19.
  10. [10] DING J. Deciphering China' s AI Dream [R].Oxford:Future of Humanity Institute, University of Oxford,2018.
  11. [11] SUK H-I,LEE S-W,SHEN D,et al. Latent Feature Representation with Stacked Auto-Encoder for AD/MCI Diagnosis [J].Brain Structure and Function,2015,220:841-859.
  12. [12] PRICE D S. A General Theory of Bibliometric and other Cumulative Advantage Processes [J].Journal of the American Society for Information Science,1976,27(5):292-306.
  13. [13] DAVATZIKOS C,FAN Y,WU X Y,et al. Detection of Prodromal Alzheimer's Disease Via Pattern Classification of Magnetic Resonance Imaging [J].Neurobiology of Aging,2008,29(4):514-523.
  14. [14] LEYDESDORFF L. Betweenness Centrality as an Indicator of the Interdisciplinarity of Scientific Journals [J].Journal of the American Society for Information Science and Technology,2007,58(9):1303-1319.
  15. [15] CHEN C M,CHEN Y,HOROWITZ M,et al. Towards an Explanatory and Computational Theory of Scientific Discovery [J].Journal of Informetrics,2009,3(3):191-209.
  16. [16] ZHU X F,SUK H-I,LEE S-W,et al. Subspace Regularized Sparse Multitask Learning for Multiclass Neurodegenerative Disease Identification [J].IEEE Transactions on Biomedical Engineering,2015,63(3):607-618.
  17. [17] JACK JR C R,BENNETT D A,BLENNOW K,et al. NIA-AA research framework:toward a biological definition of Alzheimer's disease [J].Alzheimer's & Dementia,2018,14(4):535-562.
  18. [18] NEWMAN M E J. Modularity and Community Structure in Networks [J].Proceedings of the National Academy of Sciences,2006,103(23):8577-8582.
  19. [19] KAOUNGKU N,SUKSUT K,CHANKLAN R,et al. The Silhouette Width Criterion for Clustering and Association Mining to Select Image Features [J].International Journal of Machine Learning and Computing,2018,8(1):69-73.
  20. [20] FRIZZELL T O,GLASHUTTER M,LIU C C,et al. Artificial Intelligence in Brain MRI Analysis of Alzheimer's Disease over the Past 12 Years: A Systematic Review [J/OL].Ageing Research Reviews,2022,77:101614[2024-10-06].https://doi.org/10.1016/j.arr.2022.101614.
  21. [21] GRUESO S,VIEJO-SOBERA R. Machine Learning Methods for Predicting Progression from Mild Cognitive Impairment to Alzheimer's Disease Dementia: A Systematic Review [J].Alzheimer's Research & Therapy,2021,13:1-29.
  22. [22] BATTINENI G,CHINTALAPUDI N,HOSSAIN M A,et al. Artificial Intelligence Models in the Diagnosis of Adult-Onset Dementia Disorders: A Review [J/OL].Bioengineering,2022,9(8):370[2024-09-16].https://doi.org/10.3390/bioengineering9080370.
  23. [23] EDISON P,CARTER S F,RINNE J O,et al. Comparison of MRI Based and PET Template Based Approaches in the Quantitative Analysis of Amyloid Imaging with PIB-PET [J].Neuroimage,2013,70:423-433.
  24. [24] FAREED M M S,ZIKRIA S,AHMED G,et al. ADD-Net: An Effective Deep Learning Model for Early Detection of Alzheimer Disease in MRI Scans [J].IEEE Access,2022,10:96930-96951.
  25. [25] SUK H I,LEE S W,SHEN D,et al. Hierarchical Feature Representation and Multimodal Fusion with deep Learning for AD/MCI Diagnosis [J].NeuroImage,2014,101:569-582.
  26. [26] FENG J W,ZHANG S W,CHEN L N,et al. Identification of Alzheimer's Disease Based on Wavelet Transformation Energy Feature of the Structural MRI Image and NN Classifier [J/OL].Artificial Intelligence in Medicine,2020,108:101940[2024-09-30].https://doi.org/10.1016/j.artmed.2020.101940.
  27. [27] JIANG X,ZHANG L M,QIAO L S,et al. Estimating Functional Connectivity Networks via Low-Rank Tensor Approximation With Applications to MCI Identification [J].IEEE Transactions on Biomedical Engineering,2019,67(7):1912-1920.
  28. [28] SHI Y H,ZENG W M,DENG J,et al. The Identification of Alzheimer's Disease Using Functional Connectivity Between Activity Voxels in Resting-State fMRI Data [J].IEEE Journal of Translational Engineering in Health and Medicine,2020,8:1-11.
  29. [29] FRASER K C,MELTZER J A,RUDZICZ F. Linguistic Features Identify Alzheimer's Disease in Narrative Speech [J].Journal of Alzheimer's disease,2015,49(2):407-422.
  30. [30] CHENG B,LIU M X,SHEN D G,et al. Multi-Domain Transfer Learning for Early Diagnosis of Alzheimer's Disease [J].Neuroinformatics,2017,15:115-132.

基金项目

2024年广东省医学科研基金项目(A2024637);2023年广东省高等职业教育教学质量与教学改革工程项目(2023JG167);广东省高校省级平台科研项目(2023KTSCX279)

作者简介

赖胜圣(1982—),男,汉族,广东信宜人,讲师,硕士,研究方向:医学图像处理及人工智能;通信作者:陈灿洋(2004—),男,汉族,广东深圳人,本科在读,研究方向:医学图像处理及人工智能。