Article Details

Title · Authors · Abstract · Keywords · DOI · References

Visualization Analysis of the Application of Artificial Intelligence in Alzheimer's Disease Research Based on CiteSpace

LAI Shengsheng1, ZHANG Gangping1, LIU Wenping1, CHEN Canyang1,2

(1.School of Medical Devices, Guangdong Food and Drug Vocational College, Guangzhou 510520, China; 2.School of Biomedical Engineering, Guangdong Medical University, Dongguan 523808, China)

Section:Information Application · Vol. 2025, Issue 9 · Pages:136-145,150 · 2096-4706(2025)09-0136-11 · CLC number:TP391.4 · Document code:A · DOI:10.19850/j.cnki.2096-4706.2025.09.026

Abstract

This study explores the development trend and application hotspots of Artificial Intelligence in Alzheimer's disease research through bibliometric analysis. Based on the core database of Web of Science, 3 680 related literatures from 2013 to 2023 are retrieved. CiteSpace software is used for co-occurrence analysis and keyword clustering, and the publication trend, collaborations between countries and institutions, core authors and co-cited literatures are analyzed. The research results show that the application of Artificial Intelligence in the field of Alzheimer's disease mainly focuses on three directions of image data analysis and early diagnosis, multi-modal data fusion and brain network functional connection. At the same time, task analysis and transfer learning, as emerging hotspots, show the potential of Artificial Intelligence in individualized diagnosis and long-term disease management. From the analysis of the results, it can be seen that the application of Artificial Intelligence in the diagnosis and treatment of Alzheimer's disease is in a stage of rapid development. Future research will focus on the improvement of generalization ability and multi-modal data processing ability of the algorithm to provide more accurate diagnosis and individualized treatment.

Keywords

Alzheimer's disease; visual analysis; multi-modal data fusion; Neural Network; Machine Learning

References

  1. [1] WORLD HEALTH ORGANIZATION. Global Status Report on the Public Health Response to Dementia [J].World Health Organization,2021:272.
  2. [2] FABRIZIO C,TERMINE A,CALTAGIRONE C,et al. Artificial Intelligence for Alzheimer's Disease: Promise or Challenge? [J/OL].Diagnostics,2021,11(8):1473[2024-09-27].https://doi.org/10.3390/diagnostics11081473.
  3. [3] Chen Yue, Chen Chaomei, Liu Zeyuan, etc The methodological function of CiteSpace knowledge graph [J]. Scientific Research, 2015, 33 (2): 242-253
  4. [4] CHEN C M. Visualizing and Exploring Scientific Literature with CiteSpace: An Introduction [C]//Proceedings of the 2018 Conference on Human Information Interaction & Retrieval. New Brunswick:ACM:2018:369-370.
  5. [5] LECUN Y,BENGIO Y,HINTON G. Deep Learning [J].Nature,2015,521(7553):436-444.
  6. [6] KONG X J,SHI Y J,YU S,et al. Academic Social Networks: Modeling, Analysis, Mining and Applications [J].Journal of Network and Computer Applications,2019,132:86-103.
  7. [7] ASSOCIATION A. 2018 Alzheimer's Disease Facts and Figures [J].Alzheimer's & Dementia,2018,14(3):367-429.
  8. [8] RESCE G,ZINILLI A,CERULLI G. Machine learning prediction of academic collaboration networks [J/OL].Scientific Reports,2022,12(1):21993[2024-10-03].https://www.nature.com/articles/s41598-022-26531-1.
  9. [9] REN R J,QI J L,LIN S H,et al. The China Alzheimer Report 2022 [J].General Psychiatry,2022,35(1):1-19.
  10. [10] DING J. Deciphering China' s AI Dream [R].Oxford:Future of Humanity Institute, University of Oxford,2018.
  11. [11] SUK H-I,LEE S-W,SHEN D,et al. Latent Feature Representation with Stacked Auto-Encoder for AD/MCI Diagnosis [J].Brain Structure and Function,2015,220:841-859.
  12. [12] PRICE D S. A General Theory of Bibliometric and other Cumulative Advantage Processes [J].Journal of the American Society for Information Science,1976,27(5):292-306.
  13. [13] DAVATZIKOS C,FAN Y,WU X Y,et al. Detection of Prodromal Alzheimer's Disease Via Pattern Classification of Magnetic Resonance Imaging [J].Neurobiology of Aging,2008,29(4):514-523.
  14. [14] LEYDESDORFF L. Betweenness Centrality as an Indicator of the Interdisciplinarity of Scientific Journals [J].Journal of the American Society for Information Science and Technology,2007,58(9):1303-1319.
  15. [15] CHEN C M,CHEN Y,HOROWITZ M,et al. Towards an Explanatory and Computational Theory of Scientific Discovery [J].Journal of Informetrics,2009,3(3):191-209.
  16. [16] ZHU X F,SUK H-I,LEE S-W,et al. Subspace Regularized Sparse Multitask Learning for Multiclass Neurodegenerative Disease Identification [J].IEEE Transactions on Biomedical Engineering,2015,63(3):607-618.
  17. [17] JACK JR C R,BENNETT D A,BLENNOW K,et al. NIA-AA research framework:toward a biological definition of Alzheimer's disease [J].Alzheimer's & Dementia,2018,14(4):535-562.
  18. [18] NEWMAN M E J. Modularity and Community Structure in Networks [J].Proceedings of the National Academy of Sciences,2006,103(23):8577-8582.
  19. [19] KAOUNGKU N,SUKSUT K,CHANKLAN R,et al. The Silhouette Width Criterion for Clustering and Association Mining to Select Image Features [J].International Journal of Machine Learning and Computing,2018,8(1):69-73.
  20. [20] FRIZZELL T O,GLASHUTTER M,LIU C C,et al. Artificial Intelligence in Brain MRI Analysis of Alzheimer's Disease over the Past 12 Years: A Systematic Review [J/OL].Ageing Research Reviews,2022,77:101614[2024-10-06].https://doi.org/10.1016/j.arr.2022.101614.
  21. [21] GRUESO S,VIEJO-SOBERA R. Machine Learning Methods for Predicting Progression from Mild Cognitive Impairment to Alzheimer's Disease Dementia: A Systematic Review [J].Alzheimer's Research & Therapy,2021,13:1-29.
  22. [22] BATTINENI G,CHINTALAPUDI N,HOSSAIN M A,et al. Artificial Intelligence Models in the Diagnosis of Adult-Onset Dementia Disorders: A Review [J/OL].Bioengineering,2022,9(8):370[2024-09-16].https://doi.org/10.3390/bioengineering9080370.
  23. [23] EDISON P,CARTER S F,RINNE J O,et al. Comparison of MRI Based and PET Template Based Approaches in the Quantitative Analysis of Amyloid Imaging with PIB-PET [J].Neuroimage,2013,70:423-433.
  24. [24] FAREED M M S,ZIKRIA S,AHMED G,et al. ADD-Net: An Effective Deep Learning Model for Early Detection of Alzheimer Disease in MRI Scans [J].IEEE Access,2022,10:96930-96951.
  25. [25] SUK H I,LEE S W,SHEN D,et al. Hierarchical Feature Representation and Multimodal Fusion with deep Learning for AD/MCI Diagnosis [J].NeuroImage,2014,101:569-582.
  26. [26] FENG J W,ZHANG S W,CHEN L N,et al. Identification of Alzheimer's Disease Based on Wavelet Transformation Energy Feature of the Structural MRI Image and NN Classifier [J/OL].Artificial Intelligence in Medicine,2020,108:101940[2024-09-30].https://doi.org/10.1016/j.artmed.2020.101940.
  27. [27] JIANG X,ZHANG L M,QIAO L S,et al. Estimating Functional Connectivity Networks via Low-Rank Tensor Approximation With Applications to MCI Identification [J].IEEE Transactions on Biomedical Engineering,2019,67(7):1912-1920.
  28. [28] SHI Y H,ZENG W M,DENG J,et al. The Identification of Alzheimer's Disease Using Functional Connectivity Between Activity Voxels in Resting-State fMRI Data [J].IEEE Journal of Translational Engineering in Health and Medicine,2020,8:1-11.
  29. [29] FRASER K C,MELTZER J A,RUDZICZ F. Linguistic Features Identify Alzheimer's Disease in Narrative Speech [J].Journal of Alzheimer's disease,2015,49(2):407-422.
  30. [30] CHENG B,LIU M X,SHEN D G,et al. Multi-Domain Transfer Learning for Early Diagnosis of Alzheimer's Disease [J].Neuroinformatics,2017,15:115-132.

Funding

2024 Guangdong Medical Research Fund Project (A2024637); 2023 Guangdong Province Higher Vocational Education Teaching Quality and Teaching Reform Project (2023JG167); Guangdong Provincial Platform Research Project for Universities (2023KTSCX279)

About the authors

Lai Shengsheng (1982-), male, Han ethnicity, from Xinyi, Guangdong, lecturer, master's degree, research direction: medical image processing and artificial intelligence; Corresponding author: Chen Canyang (2004-), male, Han ethnicity, from Shenzhen, Guangdong Province, undergraduate student, research direction: medical image processing and artificial intelligence.